I’m not even sure if this is a plant, but I noticed the growths on this leaf, which appeared to be plant-like. I have yet to find anyone who knows what this is, I reached out to SC DNR a few times with no reply. I took this photograph in June of this year (2019) on the Foothills Trail, a short distance after the entrance to the trail across from the parking area for Sassafrass Mountain.
this is a group of grape leaf galls, caused by an insect, a midge, Ampelomyia viticola. See this site: https://bugguide.net/node/view/657030
Dr. Steven Hill, Botanist, SCNPS